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Index > Protein center > MVP(Gene name) > Bovine
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  • MVP (Gene name),
  • Major vault protein (Protein name ),  MVP_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MVP;
    Protein name:
    Major vault protein(MVP);
    Alternative:

    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.
    Function:
    Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    890
    Sequence:
    50:
    MSMEESIIRI | PPYHYIHVLD | QNSNVSRVEV | GPKTYIRQDN | ERILFAPVRM | 
    100:
    LTVPPRHYCM | VANPVARDAQ | GTVLFDVTGQ | VRLRHADLEI | RLAQDPFPLF | 
    150:
    PGEVLEKDIT | PLQVVLPNTA | LHLKALLDFE | DKNGQKVVAG | DEWLFEGPGT | 
    200:
    YIPQKEVEVI | EIIQATVIKQ | NQALRLRARK | ECLDRDGKER | VTGEEWLVRS | 
    250:
    VGAYLPAVFE | EVLDVVDAVI | LTEKTALHLR | ARQNFRDVRG | VTRRTGEEWL | 
    300:
    VTVQDTEAHV | PDVYEEVMGV | VSVTTLGPHN | YCVILDPVGP | DGKNQLGQKL | 
    350:
    VFKGEQSFFL | QPGEKLERGI | QNVYVLSEQQ | GLLLRALQPL | EEGEGKEKVS | 
    400:
    HQAGDHWLIR | GPLEYVPPAK | VEVVEERQAI | PLDENEGIYV | QDVKTGRVRA | 
    450:
    VIGSTYMLTQ | DEVLWEKELP | PGVEELLNKG | QDPLADRGEK | ETSKTPKLST | 
    500:
    PRNKTRVVSY | RVPHNAAVQV | YDYREKKARV | VFGPELVLLG | PEEQFTVLSL | 
    550:
    SAGRPKRPHA | RRTLCLLLGP | DFFTDVITIE | TADHARLQLQ | LAYNWHFELS | 
    600:
    DRKDPQETAK | LFSVPDFVGD | ACKAIASRVR | GAVASVTFDD | FHKNSARIIR | 
    650:
    TAVFGFETQE | TKGPDTMALP | QPRDRAVFPQ | NGLVVSSVDV | QSVEPVDQRT | 
    700:
    RDALQRSVQL | AIEIATNSQE | AAAKHEAQRL | EQEARGRLER | QKILDQSEAE | 
    750:
    KARRELLELE | ALSTAVESTG | TAKAEAESRA | EAARIEGEGA | VLQAKLKAEA | 
    800:
    LAIETEAELE | RVKKVRELEL | LYARAQLELE | VSKAQQLAEV | EVKKFKQMTE | 
    850:
    ALGPSTIRDM | AVAGPEMQVK | LLQSLGLKST | LITDGSTPIN | LFNTALGLLG | 
    890:
    LGAEAQPPAK | KPTGGPSVQE | GLLPISTAAP | LTLGNNQVVP | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
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    CLIA Kit for Bovine MVP
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    Polyclonal Antibody for Bovine MVP
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    P1071Rb-r
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    Polyclonal Antibody for Bovine MVP
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    Polyclonal Antibody for Bovine MVP
    Polyclonal Antibody for Bovine MVP
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    Packing:
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    Polyclonal Antibody for Bovine MVP
    Monoclonal Antibody for Bovine MVP
    Monoclonal Antibody for Bovine MVP
    Monoclonal Antibody for Bovine MVP
    Monoclonal Antibody for Bovine MVP
    Monoclonal Antibody for Bovine MVP
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    Protein for Bovine MVP

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    References
    1. 1.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2005-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Crossbred X Angus.
      tissue: Ileum.
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